The Role of Dentate Gyrus Neurogenesis in Neuropsychiatric Disorders
نویسندگان
چکیده
The special issue reviews the most recent developments in dentate gyrus (DG) neurogenesis with regard to neuropsychiatric disorders. A few laboratories worldwide have contributed to this special issue, and their contributions have showcased the current efforts in understanding the functional significance of DG neurogenesis in depression, psychosis, and addiction. Additionally, a promising therapeutic strategy for treating radiation therapy disorders is reviewed.The review and research articles in this special issue indicate that DG neurogenesis can be conceptualized as a form of plasticity and that the alterations in DG neurogenesis can predict a spectrum of disorders associated with the hippocampus. Highlights from the papers in the special issue are summarized below.
منابع مشابه
O18: Role of Adult Hippocampal Neurogenesis in Anxiety Disorders
Neurogenesis occurs throughout life in several regions of the brain. In this lecture, a new sight for the role of the dentate gyrus and adult hippocampal neurogenesis in anxiety disorders will be discussed. The region that has obtained the most attention for its involvement in the neurogenesis of affective and anxiety disorders are the hippocampal and dentate gyrus. Evidence strongly suggests t...
متن کاملEffects of male phermoneses on neuronal morphology in the dentate gyrus of hippocampus of female Mice
Background & Aims: Neurogenesis in the adult mammal brain occurs throughout life. Adult neurogenesis has been clearly demonstrated in the sub granular zone (SGZ) of the dentate gyrus (DG) in the hippocampus. Pheromones that plays an essential role in the development of the central nervous system. The male pheromones are involved in regulating neurogenesis in both the olfactory bulb and hippocam...
متن کاملTbr2 is essential for hippocampal lineage progression from neural stem cells to intermediate progenitors and neurons.
Neurogenesis in the dentate gyrus has been implicated in cognitive functions, including learning and memory, and may be abnormal in major neuropsychiatric disorders, such as depression. Dentate neurogenesis is regulated by interactions between extrinsic factors and intrinsic transcriptional cascades that are currently not well understood. Here we show that Tbr2 (also known as Eomes), a T-box tr...
متن کاملAdult neurogenesis, mental health, and mental illness: hope or hype?
Psychiatric and neurologic disorders take an enormous toll on society. Alleviating the devastating symptoms and consequences of neuropsychiatric disorders such as addiction, depression, epilepsy, and schizophrenia is a main force driving clinical and basic researchers alike. By elucidating these disease neuromechanisms, researchers hope to better define treatments and preventive therapies. Rese...
متن کاملبررسی اثر عصاره الکلی دانه گیاه ارزن پروسو (Panicum miliaceam) بر دانسیته نورونی ژیروس دندانه ای هیپوکامپ در موش سفید آزمایشگاهی نر
Background and Objective: The evolution of species in the brain, neurons in some brain areas process has been confirmed. This process is known as Neurogenesis. Neurogenesis process in two areas of the brain, the anterior adult mammals, including regional sub- ventriculus and dentate gyrus in various species, including rodents, primates and humans occurs. Millet is the family of Poaceae The seed...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2013 شماره
صفحات -
تاریخ انتشار 2013